Intrajugular Vein Delivery of AAV9-RNAi Prevents Neuropathological Changes and Weight Loss in Huntington's Disease Mice
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چکیده
منابع مشابه
Chronic Consumption of Kombucha and Black Tea Prevents Weight Loss in Diabetic Rats
OBJECTIVE: Diabetes mellitus (DM) is a chronic metabolic disease which affects many organ systems in the body and is associated with a progressive weight loss. Many diabetic patients used to consume herbal remedies to relieve their symptoms. Black tea and its fermented remedy which is made by cultivating the Kombucha mushroom in a mixture of warm tea and sugar are widely used by diabetic patien...
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Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. The aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of AD. Methods: Adult male Albino Wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. The rats were randomly assigned t...
متن کاملQuantitative neuropathological changes in presymptomatic Huntington's disease.
Morphometric studies of the tail of the caudate nucleus, the site where the pathology is first seen, were performed on 16 brain specimens collected from individuals at risk for inheriting Huntington's disease (HD). Medical records and information obtained from immediate family members indicated that all had died without symptoms of HD. Six individuals had 37 or more CAG repeats and were designa...
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Ketotifen is a potent, safe and long acting antihistamine that is effective in treatment of asthma and its use is believed to causes weight gain and drowsiness. Cyproheptadine, an antihistamine, has anticholinergic and antiserotonergic effects, and causes increases of the appetite and weight gain. In this study the effects of different doses of ketotifen and/or cyproheptadine on the appeti...
متن کاملRPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice.
PURPOSE Recent in vitro evidence has shown that RPE65 is the isomerohydrolase that converts all-trans retinyl ester to 11-cis retinal, the chromophore for visual pigments in vertebrates. Homozygous RPE65 knockout (Rpe65-/-) mice lack 11-cis retinoids and have early cone degeneration. The purpose of this study is to determine whether RPE65 gene delivery restores the isomerohydrolase activity and...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2014
ISSN: 1525-0016
DOI: 10.1038/mt.2013.289